Institute of Applied Physics - Biophysics
> Zum Inhalt

Gerhard Schütz

Email:

Phone: +43 - (0)1 - 58801 - 13480

 

Research Interest

Developing and applying single molecule spectroscopy and imaging methods for the in vivo analysis of plasma membrane proteins and lipids.

Understanding the functional role of plasma membrane nanostructures.

Molecular mechanism of early T cell signaling.

 

Scientific and Professional Background

1988-1995Study of Technical Physics at the Johannes Kepler University Linz
1995Master Degree “Studies of the dynamics of single membrane constituents using fluorescence microscopy"
1997PhD with “Single Molecule Optical Microscopy: Applications to Biosystems”
1997-2001Postdoctoral fellow at the Biophysics Institute, Johannes Kepler University Linz
2001-2004University Assistant at the Biophysics Institute, Johannes Kepler University Linz
2004Venia Docendi (Habilitation) in Biophysics, Johannes Kepler University Linz
2004-2011Associate Professor at the Biophysics Institute, Johannes Kepler University Linz
since 2011Full Professor at the Institute of Applied Physics, Vienna University of Technology

 

Honors

Amersham Pharmacia Biotech Award, 2001

Upper-Austrian Award for Young Scientists, 2003

START-Award, 2004

 

Memberships

Junge Kurie of the Austrian Academy of Sciences

Austrian Society for Biomedical Engineering (ÖGMBT): board member

Austrian Biophysical Society (ÖBG): vice president (2010-2013); president (2013-2015)

Austrian Physical Society (ÖPG)

American Biophysical Society

BIOINTERFACE network at TU Wien

 

Publications

List of Publications of Gerhard J. Schütz

Invited Reviews

Book articles

 

List of Publications of Gerhard J. Schütz

 

Eva Sevcsik and Gerhard J. Schütz

Bioessays 38 (2016) 129-139

With or without rafts? Alternative views on cell membranes

 

Andreas Arnold, Eva Sevcsik, Gerhard J. Schütz

J. Phys D: Appl. Phys 49 (2016) 364002

Monte Carlo simulations of protein micropatterning in biomembranes: effects of immobile sticky obstacles

 

Florian Baumgart, Andreas Arnold, Konrad Leskovar, Kaj Staszek, Martin Fölser, Julian Weghuber, Hannes Stockinger, Gerhard J. Schütz

Nature Methods 13 (2016) 661-664

Varying label density allows artifact-free analysis of membrane protein nano clusters

 

Bianca Buchegger, Johannes Kreutzer, Birgit Plochberger, Richard Wollhofen, Dmitry Sivun, Jaroslaw Jacak, Gerhard J. Schütz, Ulrich Schubert, and Thomas A. Klar

ACS Nano 10 (2016) 1954-1959

STED-Lithography with Mercapto-Functional Polymers

 

M. Brameshuber, E. Sevcsik, B. K. Rossboth, C. Manner, HP. Deigner, B. Peksel, M. Péter, Z. Török, A. Hermetter, G. J. Schütz

Biophys. J. 110 (2016) 205-213

Oxidized Phospholipids Inhibit the Formation of Cholesterol-Dependent Plasma Membrane Nanoplatforms

 

Reinhard Mayr, Christoph Mahringer, Roland Thünauer, Thomas Haselgrübler, Michaela Haider, Gerhard J. Schütz, Alois Sonnleitner, Jan Hesse

Biosens. Bioelectr. 106 (2016) 1 - 6

A microfluidic platform for transcription- and amplification-free detection of zepto-mole amounts of nucleic acid molecules

 

Eva Sevcsik, Mario Brameshuber, Martin Fölser, Julian Weghuber, Alf Honigmann, Gerhard J. Schütz

Nat. Commun. 106 (2015) L33-L35

GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane

 

E. Klotzsch, A. Smorodchenko, L. Löfler, R. Moldzio, E. Parkinson, G. J. Schütz, E. E. Pohl

Proc. Natl. Acad. Sci. USA 112 (2015) 130-135

Super-resolution microscopy reveals spatial separation of UCP4 and F0F1-ATP synthase in neuronal mitochondria

 

A. Anderluh, E. Klotzsch, J. Ries, A.W.A.F. Reismann, S. Weber, M. Fölser, F. Koban, M. Freissmuth, H. H. Sitte, G. J. Schütz

Biophys. J. 106 (2014) L33-L35

Tracking Single Serotonin Transporter Molecules at the Endoplasmic Reticulum and Plasma Membrane

 

P. Lanzerstorfer, D. Borgmann, G. J. Schütz; S. M. Winkler; O. Höglinger; J. Weghuber

PLoS One 9 (2014) e92151

Quantification and kinetic analysis of Grb2-EGFR interaction on micro-patterned surfaces for the characterization of EGFR-modulating substances

 

C. Lamprecht, B. Plochberger, V. Ruprecht, S. Wieser, C. Rankl, E. Heister, B. Unterauer, M. Brameshuber, J. Danzberger, E. Flahaut, G. J. Schütz, P. Hinterdorfer, A. Ebner

Nanotechnology 25 (2014) 125704

A single-molecule approach to explore binding, uptake and transport of cancer cell targeting nanotubes

 

A. Anderluh, E. Klotzsch, A. W. A. F. Reismann, M. Brameshuber, O. Kudlacek, A. Hauck Newman, H. H. Sitte, G. J. Schütz

J. Biol. Chem. 289 (2014) 4387-4394

Single Molecule Analysis Reveals Coexistence of Stable Serotonin Transporter Monomers and Oligomers in the Live Cell Plasma Membrane

 

A.-M. Lipp, K. Juhasz, C. Paar, C. Ogris, P. Eckerstorfer, R. Thuenauer, J. Hesse, B. Nimmervoll, H. Stockinger, G. J. Schütz, U. Bodenhofer, Z. Balogi, A. Sonnleitner

PLoS One 9 (2014) e85934

Lck mediates signal transmission from CD59 to the 1 TCR/CD3 pathway in Jurkat T cells

 

Florian Forster, Wolfgang Paster, Verena Zojer, Herbert B. Schiller, Philipp Schatzlmaier, Stefan Sunzenauer, Anna Saliba, Paul Eckerstorfer, Gerhard Schütz, Johannes A. Schmid, Gerhard J. Zlabinger, Elisabeth Naschberger, Michael Stürzl and Hannes Stockinger

J. Immunol. 192 (2014) 771-781

GBP-1 mediated interaction of the T cell antigen receptor signaling with the cytoskeleton

 

Elke Fürtbauer, Jan Zaujec, Pavel Uhrin, Ingrid Raab, Michele Weber, Helga Schachner, Miroslav Bauer, Gerhard J. Schütz, Bernd R. Binder, Michael Sixt, Dontscho Kerjaschki, and Hannes Stockinger

Immunol. Lett. 154 (2013) 31-41

Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells

 

E. Klotzsch and Gerhard J. Schütz

Biophys. J. 104 (2013) 1670-1675

Improved ligand discrimination by force-induced unbinding of the T cell receptor from peptide-MHC

 

J. Jacak, H. Schnidar, L. Muresan, G. Regl, A. Frischauf, F. Aberger, G. J. Schütz, J. Hesse

J. Biotechnol. 164 (2013) 525-530

Expression analysis of multiple myeloma CD138 negative progenitor cells using single molecule microarray readout

 

S. Sunzenauer, V. Zojer, M. Brameshuber, A. Tröls, J. Weghuber, H. Stockinger, G. J. Schütz

Cytometry A 83 (2013) 847-854

Determination of binding curves via protein micropatterning in vitro and in living cells

 

B. A. Aekbote, J. Jacak, G. J. Schütz, E. Csanyi, Z. Szegletes, P. Ormos, L. Kelemen

Eur. Polym. J. 48 (2012) 1745-1754

Aminosilane-based functionalization of two-photon polymerized 3D SU-8 microstructures

 

M. Axmann, J. B. Huppa, M. M. Davis, G. J. Schütz

Biophys J. 103 (2012) L17-L19

Determination of Interaction Kinetics between the T Cell Receptor and Peptide-loaded MHC class II via Single Molecule Diffusion Measurements

 

R. A. Alexander, G. W. Prager, J. Mihaly-Bison, P. Uhrin, S. Sunzenauer, B. R. Binder, G. J. Schütz, M. Freissmuth, J.M. Breuss

Cardiovasc. Res. 94 (2012) 125-135

VEGF-induced endothelial cell migration requires urokinase receptor (uPAR)-dependent integrin redistribution

 

I. Gombos, T. Crul, S. Piotto, B. Güngör, Z. Török, G. Balogh, M. Péter, J. P. Slotte, F. Campana1, A.-M. Pilbat, N. Tóth, Z. Literati-Nagy, L. Vigh Jr., A. Glatz, M. Brameshuber, G. J. Schütz, A. Hevener, M. A. Febbraio , I. Horváth and L. Vígh

PLoS One 6 (2011) e28818

Membrane-lipid therapy in operation: The HSP co-inducer BGP-15 activates stress signal transduction pathways by remodeling plasma membrane rafts

 

Julian Weghuber, Michael C. Aichinger, Mario Brameshuber, Stefan Wieser, Verena Ruprecht, Birgit Plochberger, Josef Madl, Andreas Horner, Siegfried Reipert, Karl Lohner, Tamás Henics, Gerhard J. Schütz

Biochim. Biophys. Acta 1808 (2011) 2581-2590

Cationic amphipatic peptides accumulate sialylated proteins and lipids in the plasma-membrane of eukaryotic host cells

 

Verena Ruprecht, Stefan Wieser, Didier Marguet, Gerhard J. Schütz

Biophys J. 100 (2011) 2839-2845

Spot variation fluorescence correlation spectroscopy allows for superresolution chronoscopy of confinement times in membranes

 

R. Schmidt, J. Jacak, C. Schirwitz, V. Stadler, G. Michel, N. Marmé, G. J. Schütz, J. Hoheisel, J. P. Knemeyer

J. Proteome Res. 10 (2011) 1316-1322

Single molecule detection on a protein array assay platform for the exposure of a tuberculosis antigen

 

M. C. Aichinger, M. Ginzler, J. Weghuber, L. Zimmermann, K. Riedl, G. J. Schütz, E. Nagy, A. von Gabain, R. J. Schweyen, T. Henics

Vaccine 29 (2011) 426-436

Adjuvating the adjuvant: facilitated delivery of an immunomodulatory oligonucleotide to TLR9 by a cationic antimicrobial peptide in dendritic cells

 

M. Brameshuber, J. Weghuber, V. Ruprecht, I. Gombos, I. Horváth, L. Vigh, P. Eckerstorfer, E. Kiss, H. Stockinger, G. J. Schütz

J. Biol. Chem. 285 (2010) 41765-41771

Imaging of mobile long-lived nanoplatforms in the live cell plasma membrane

 

J. Madl, J. Weghuber, R. Fritsch, I. Derler, M. Fahrner, I. Frischauf, B. Lackner, C. Romanin, G. J. Schütz

J. Biol. Chem. 285 (2010) 41135-41142

Resting-state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells

 

Birgit Plochberger, Thomas Stockner, Salvatore Chiantia, Mario Brameshuber, Julian Weghuber, Albin Hermetter, Petra Schwille, Gerhard J. Schütz

Langmuir 26 (2010) 17322-17329

Cholesterol slows down the lateral mobility of an oxidized phospholipid in a supported lipid bilayer

 

J. Weghuber, A. M. Lipp, J. Stadlbauer, M. C. Aichinger, V. Ruprecht, A. Sonnleitner, G. J. Schütz, T. Henics

Cell Biol. Int. 34 (2010) 1109-1112

Antimicrobial and immunostimulatory peptide, KLK, induces an increase in cytosolic Ca2+ concentration by mobilizing Ca2+ from intracellular stores

 

J. Weghuber, S. Sunzenauer, B. Plochberger, M. Brameshuber, T. Haselgrübler, G. J. Schütz

Anal. Bioanal. Chem 397 (2010) 3339-3347

Temporal resolution of protein-protein interactions in the live-cell plasma membrane

 

J. Jacak, C. Hesch, J. Hesse, G. J. Schütz

Anal. Chem. 82 (2010) 4288-4292

Identification of immobile single molecules using polarization-modulated asynchronous TDI-mode scanning

 

J. Weghuber, S. Sunzenauer, M. Brameshuber, B. Plochberger, C. Hesch, G. J. Schütz

J. Vis. Exp. 37 (2010)

In-vivo detection of protein-protein interactions on micro-patterned surfaces

 

M. Duman, M. Pfleger, R. Zhu, C. Rankl, L. A. Chtcheglova, I. Neundlinger, B. L. Bozna, B. Mayer, M. Salio, D. Shepherd, P. Polzella,
M. Moertelmaier, G. Kada, A. Ebner, M. Dieudonne, G. J. Schütz, V. Cerundolo, F. Kienberger, P. Hinterdorfer

Nanotechnology 21 (2010) 115504

Improved localization of cellular membrane receptors using combined fluorescence microscopy and simultaneous topography and recognition imaging

 

L. Muresan, J. Jacak, E. P. Klement, J. Hesse, G. J. Schütz

IEEE Trans. Nanotechnology 9 (2010) 51-58.

Microarray analysis at single molecule resolution

 

L. Zimmermann, W. Paster, J. Weghuber, P. Eckerstorfer, H. Stockinger, G. J. Schütz

J. Biol. Chem. 285 (2010) 6063-6070.

Direct observation and quantitative analysis of Lck-exchange between plasma membrane and cytosol in living T cells

 

J. B. Huppa, M. Axmann, M. A. Mörtelmaier, B. F. Lillemeier, E. W. Newell, M. Brameshuber, L. O. Klein, G. J. Schütz, M. M. Davis

Nature 463 (2010) 963-967.

TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity

 

V. Ruprecht, M. Brameshuber, G. J. Schütz

Soft Matter 6 (2010) 568-581.

Two-color single molecule tracking combined with photobleaching for the detection of rare molecular interactions in fluid biomembranes

 

S. Wieser, J. Weghuber, M. Sams, H. Stockinger, G. J. Schütz

Soft Matter 5 (2009) 3287-3294.

Cell-to-cell variability in the diffusion constants of the plasma membrane proteins CD59 and CD147

 

C. Hesch, J. Hesse, J. Jacak, G. J. Schütz

J. Microscopy 234 (2009) 251-254.

Two-Stage focus hold system for rapid ultra-sensitive readout of large area biochips

 

M. Brameshuber, M. Schwarzenbacher, M. Kaltenbrunner, C. Hesch, W. Paster, J. Weghuber, B. Heise, A. Sonnleitner, H. Stockinger, G. J. Schütz

Nat. Methods 6(2009) 183-184.

Reply to "Uncoupling diffusion and binding in FRAP experiments“

 

W. Paster, C. Paar, P. Eckerstorfer, A. Jakober, K. Drbal, G. J. Schütz, A. Sonnleitner, H. Stockinger

J. Immunol. 182 (2009) 2160-2167.

Genetically encoded Förster Resonance Energy Transfer sensors for the conformation of the Src family kinase Lck

 

S. Rhode, R. Grurl, M. Brameshuber, A. Hermetter, G. J. Schütz

J Biol Chem 284 (2009) 2258-2265.

Plasma membrane fluidity affects transient immobilization of oxidized phospholipids in endocytotic sites for subsequent uptake

 

M. Schwarzenbacher, M. Kaltenbrunner, M. Brameshuber, C. Hesch, W. Paster, J. Weghuber, B. Heise, A. Sonnleitner, H. Stockinger, G. J. Schütz

Nat. Methods 5 (2008) 1053-1060.

Micropatterning for quantitative analysis of protein-protein interactions in living cells

 

S. Wieser, M. Axmann, Gerhard J. Schütz

Biophys. J. 95 (2008) 5988-6001.

Versatile Analysis of Single Molecule Tracking Data by Comprehensive Testing against Monte Carlo Simulations

 

Peter Veranic, Marusa Lokar, Gerhard J. Schütz, Julian Weghuber, Stefan Wieser, Henry Hagerstrand, Veronika Kralj-Iglic, Ales Iglic

Biophys J. 95 (2008) 4416-4425

Different types of cell-to-cell connections mediated by nanotubular structures

 

Clemens Hesch, Jan Hesse, Gerhard J. Schütz

Biosens. Bioelectr. 23 (2008) 1891-1895.

Implementation of alternating excitation schemes in a biochip-reader for quasi-simultaneous multi-color single-molecule detection

 

C. Paar, W. Paster, H. Stockinger, G. J. Schütz, M. Sonnleitner, A. Sonnleitner

Cytometry A 73 (2008) 442-450.

High Throughput FRET Screening of the Plasma Membrane Based on TIRFM

 

S. Wieser, G. J. Schütz, M. E. Cooper, H. Stockinger

Appl. Phys. Lett. 91 (2007) 233901.

Single Molecule Diffusion Analysis on Cellular Nanotubules: Implications on Plasma Membrane Structure below the Diffraction-Limit

 

H. Krobath, G.J. Schütz, R. Lipowsky, T.R. Weikl

Europhys. Lett. 78 (2007) 38003.

Lateral diffusion of receptor-ligand bonds in membrane adhesion zones: Effect of thermal membrane roughness

 

J.Hesse, J.Jacak, G.Regl, T.Eichberger, F.Aberger, R.Schlapak, S.Howorka, L.Muresan, A.-M.Frischauf, G.J.Schütz

Proc. SPIE, 6444 (2007) 64440F.

Single molecule fluorescence microscopy for ultra-sensitive RNA expression profiling

 

Karel Drbal, Manuel Moertelmaier, Christa Holzhauser, Arshad Muhammad, Elke Fürtbauer, Stefan Howorka, Maria Hinterberger, Hannes Stockinger, Gerhard J. Schütz

Int. Immunol. 19 (2007) 675-684.

Single molecule microscopy reveals heterogeneous dynamics of lipid raft components upon T cell receptor engagement

 

Stefan Wieser, Manuel Moertelmaier, Elke Fürtbauer, Hannes Stockinger, Gerhard J. Schütz

Biophys. J. 92 (2007) 3719-3728.

(Un)confined Diffusion of CD59 in the Plasma Membrane determined by High-resolution Single Molecule Microscopy

 

T.A.Pagler, S.Golsabahi, M.Doringer, S.Rhode, G.J.Schütz, M.Pavelka, C. Wadsack, M.Gauster, A.Lohninger, H.Laggner, W.Strobl, H.Stangl

J. Biol. Chem. 281 (2006) 38159-38171.

A Chinese hamster ovarian cell line imports cholesterol by high density lipoprotein degradation

 

J.Hesse, J.Jacak, M.Kasper, G.Regl, T.Eichberger, M.Winklmayr, F.Aberger, M.Sonnleitner, R.Schlapak, S.Howorka, L.Muresan, A.-M.Frischauf, G.J.Schütz

Genome Res. 16 (2006) 1041-1045.

RNA expression profiling at the single molecule level

 

J.Madl, S.Rhode, H.Stangl, H.Stockinger, P.Hinterdorfer, G.J.Schütz, G.Kada

Ultramicroscopy 106 (2006) 645-651.

A Combined Optical and Atomic Force Microscope for Live Cell Investigations

 

T.A.Pagler, S.Rhode, A.Neuhofer, H.Laggner, W.Strobl, C.Hinterndorfer, I.Volf, M.Pavelka, E.R.M.Eckhardt, D.van der Westenhuyzen, G.J.Schütz, H.Stangl

J. Biol. Chem. 281 (2006) 11193-11204.

SR-BI mediated HDL endocytosis leads to HDL resecretion facilitating cholesterol efflux

 

M.Moertelmaier, M. Brameshuber, M. Linimeier, G. J. Schütz, H. Stockinger

Appl. Phys. Lett. 87 (2005) 263903.

Thinning Out Clusters while Conserving Stoichiometry of Labeling

This paper has been included in the January 1, 2006 issue of Virtual Journal of Biological Physics Research.

 

M.Sonnleitner, G.Freudenthaler, J.Hesse, G.J.Schütz

Proc. SPIE 5699 (2005) 202-210.

High-throughput scanning with single-molecule sensitivity

 

J.Jacak, J.Hesse, C.Hesch, M.Kasper, F.Aberger, A.Frischauf, M.Sonnleitner, G.Freudenthaler, S.Howorka, G.J.Schütz

Proc. SPIE 5699 (2005) 442-449.

Ultrasensitive DNA detection on microarrays

 

E.Füreder-Kitzmüller, J.Hesse, A.Ebner, H.J.Gruber, G.J.Schütz

Chem.Phys.Lett. 404 (2005) 13-18.

Non-exponential bleaching of single bioconjugated Cy5 molecules

 

J.Hesse, M.Sonnleitner, A.Sonnleitner, G.Freudenthaler, J.Jacak, O.Höglinger, H.Schindler, G.J.Schütz

Anal.Chem. 76 (2004) 5960-5964.

Single molecule reader for high-throughput bioanalysis

 

S.Rhode, A.Breuer, J.Hesse, M.Sonnleitner, T.A.Pagler, M.Doringer, G.J.Schütz, H.Stangl

Cell Biochem.Biophys. 41 (2004) 343-356.

Visualization of the uptake of individual HDL particles in living cells via the scavenger receptor class B type I

 

E.Umlauf, E.Csaszar, M.Mörtelmaier, G.J.Schütz, R.G.Parton, R.Prohaska

J.Biol.Chem. 279 (2004) 23699 – 23709.

Association of Stomatin with Lipid Bodies</a</p>

 

G.J.Schütz, M.Axmann, S.Freudenthaler, H.Schindler, K.Kandror, J.C.Roder, A.Jeromin

Microsc.Res.Tech. 63 (2004) 159-167.

Visualization of vesicle transport along and between distinct pathways in neurites of living cells

 

G.Staffler, A.Szekeres, G.J.Schütz, M.D.Säemann, E.Prager, M.Zeyda, K.Drbal, G.J.Zlabinger, T.M.Stulnig, H.Stockinger

J.Immunol. 171 (2003) 1707-1714.

Selective Inhibition of T Cell Activation via CD147 through novel Modulation of Lipid Rafts

 

W.Baumgartner, G.J.Schütz, J.Wiegand, N.Golenhofen, D.Drenckhahn

J.Cell Sci. 116 (2003) 1001-1011.

Cadherin Function probed by Laser Tweezer and Single Molecule Fluorescence in Vascular Endothelial Cells

 

V. Borisenko, T. Lougheed, J. Hesse, E. Füreder-Kitzmüller, N. Fertig, J. Behrends, A. Woolley, G.J. Schütz

Biophys.J. 84 (2003) 612-622.

Simultaneous Optical and Electrical Recording of Single Gramicidin Channels

 

Manuel Mörtelmaier, Eva J. Kögler, Jan Hesse, Max Sonnleitner, Lukas A. Huber, Gerhard J. Schütz

Single Mol. 3 (2002) 225-231.

Single Molecule Microscopy in Living Cells: Subtraction of Autofluorescence Based on Two Color Recording

 

Wolfgang Drobnik, Hana Borsukova, Alfred Böttcher, Alexandra Pfeiffer, Gerhard Liebisch, Gerhard J. Schütz, Hansgeorg Schindler, Gerd Schmitz

Traffic 3 (2002) 268-278.

Apo AI/ABCA1-Dependent and HDL3-Mediated Lipid Efflux from Compositionally Distinct Cholesterol-Based Microdomains

 

B.Pragl, A.Koschak, M.Trieb, G.Obermaier, W.A.Kaufmann, U.Gerster, E.Blanc, C.Hahn, H.Prinz, G.J.Schütz, H.Darbon, H.J.Gruber, H.-G.Knaus

Bioconjugate Chem. 13 (2002) 416-425.

Synthesis, characterization and application of Cy-dye- and Alexa-dye-labeled hongotoxin1 analogues – the first high affinity fluorescence probes for voltage-gated K+ channels

 

G.Freudenthaler, M.Axmann, H.Schindler, B.Pragl, H.-G.Knaus, G.J.Schütz

Histochem.Cell Biol. 117 (2002) 197-202.

Ultrasensitive pharmacological characterization of the voltage-gated potassium

channel KV1.3 studied by single molecule fluorescence microscopy

 

A.Pfeiffer, A.Böttcher, E.Orsó, M.Kapinsky, P.Nagy, A.Bodnár, I.Spreitzer, G.Liebisch, W.Drobnik, K.Gempel, M.Horn, S.Holmer, T.Hartung,
G.Multhoff, G.J.Schütz, H.Schindler, A.J.Ulmer, H.Heine, F.Stelter, C.Schütt, G.Rothe, J.Szöllôsi, S.Damjanovich and G.Schmitz

Eur.J.Immunol. 31 (2001) 3153-3164.

Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts

 

A.Pfeiffer, M.Kapinsky, E.Orsó, G.J.Schütz, H.Schindler, P.Nagy, G.Rothe, J.Szöllösi, S.Damjanovich, and G.Schmitz

Single Mol. 2 (2001) 113-115.

The Cholesterol Content of the Plasma Membrane as a Regulator of CD14 Dependent Signal Transduction

 

W.Trabesinger, B.Hecht, U.P.Wild, G.J.Schütz, H.Schindler, and Th.Schmidt

Anal.Chem. 73 (2001) 1100-1105.

Statistical Analysis of Single-Molecule Colocalization Assays

 

B.Immitzer, Ch.Etzlstorfer, R.A.Obermüller, M.Sonnleitner, G.J.Schütz, H.Falk

Monatsh.Chem. 131 (2000) 1039-1045.

On the Photochemical Proton Expulsion Capability of Fringelite D – a Model of the Protist Photosensory Pigments of the Stentorin and Blepharismin Types

 

G.J.Schütz, J.Hesse, G.Freudenthaler, V.Ph.Pastushenko, H.-G.Knaus, B.Pragl, H.Schindler

Single Mol. 1 (2000) 153-157.

3D Mapping of Individual Ion Channels on Living Cells

 

G.J.Schütz, G.Kada, V.Ph.Pastushenko, and H.Schindler

EMBO J. 19 (2000) 892-901.

Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy

 

G.J.Schütz, V.Ph.Pastushenko, H.J.Gruber, H.-G.Knaus, B.Pragl, and H.Schindler

Single Mol. 1 (2000) 25-31.

3D Imaging of Individual Ion Channels in Live Cells at 40nm Resolution

 

A.Sonnleitner, G.J.Schütz, and Th.Schmidt

Biophys.J. 77 (1999) 2638-2642.

Free Brownian Motion of Individual Lipid Molecules in Biomembranes

 

G.S.Harms, M.Sonnleitner, G.J.Schütz, H.J.Gruber, and Th.Schmidt

Biophys.J. 77 (1999) 2864-2870.

Single-Molecule Anisotropy Imaging

 

M.Sonnleitner, G.J.Schütz, and Th.Schmidt

Chem.Phys.Lett. 300 (1999) 221-226.

Imaging Individual Molecules by Two-photon Excitation

 

R.A.Obermüller, G.J.Schütz, H.J.Gruber, and H.Falk

Monatsh.Chem. 130 (1999) 275-281.

Concerning regioselective photochemical intermolecular proton transfer from Hypericin

 

W.Trabesinger, G.J.Schütz, H.J.Gruber, H.Schindler, and Th.Schmidt

Anal.Chem. 71(1999) 279-283.

Detection of Individual Oligonucleotide Pairing by Single-Molecule Microscopy

 

G.J.Schütz, W. Trabesinger and Th.Schmidt

Biophys.J. 74(1998) 2223-2226.

Direct Observation of Ligand Colocalization on Individual Receptor Molecules

 

G.J.Schütz, H.Schindler, and Th.Schmidt

Biophys.J. 73(1997) 1073-1080.

Single-Molecule Microscopy on Model Membranes Reveals Anomalous Diffusion

 

G.J.Schütz, H.J.Gruber, H.Schindler, and Th.Schmidt

J.Luminescence 72-74(1997) 18-21.

Fluorophores for Single-Molecule Microscopy

 

G.J.Schütz, H.Schindler, and Th.Schmidt

Opt.Lett. 22(1997) 651-653.

Imaging Single-Molecule Dichroism

 

Th.Schmidt, G.J.Schütz, H.J.Gruber, and H.Schindler

Anal.Chem. 68(1996) 4397-4401.

Local Stoichiometries Determined by Counting Individual Molecules

 

Th.Schmidt, G.J.Schütz, W.Baumgartner, H.J.Gruber, and H.Schindler

J.Phys.Chem. 99(1995) 17662-17668.

Characterization of Photophysics and Mobility of Single Molecules in a Fluid Lipid Membrane

 

Th. Schmidt, G.J. Schütz, W. Baumgartner H.J. Gruber, and H. Schindler

Proc.Natl.Acad.Sci. USA 93(1996) 2926-2929.

Imaging of Single Molecule Diffusion

 

Up

 

Invited Reviews

     

  1. Florian Baumgart, Gerhard J. Schütz

    Biochim Biophys Acta, in press

    Detecting protein association at the T cell plasma membrane

  2.  

  3. Z.Török, T.Crul, B.Maresca, G.J.Schütz, F.Viana, M.M.Vijayan, S.Piotto, M.Brameshuber, G.Balogh, M.Péter, A.Porta, L.Dindia, A.Trapani, I.Gombos, A.Glatz, B.Gungor, B.Peksel, L.Vigh Jr., B.Csoboz, I.Horváth, P.L.Hooper, J.L.Harwood, and L.Vigh

    Biochim. Biophys. Acta 1838 (2014) 1594-1618

    The membranes are heat sensors: From lipid-controlled molecular switches to therapeutic applications

  4.  

  5. Enrico Klotzsch, Gerhard J. Schütz

    Phil. Trans. R. Soc. B. 368 (2013) 20120033

    A critical survey of methods to detect plasma membrane rafts

  6.  

  7. Isabella Derler, Josef Madl, Gerhard J. Schütz, Christoph Romanin

    Adv. Exp. Med. Biol. 740 (2012) 383-410.

    Structure, regulation and biophysics of ICRAC, STIM/Orai1

  8.  

  9. Mario Brameshuber, Gerhard J. Schütz

    Methods Enzymol. 505 (2012) 159-186.

    Detection and Quantification of Biomolecular Association in Living Cells using Single Molecule Microscopy

  10.  

  11. Verena Ruprecht, Markus Axmann, Stefan Wieser, Gerhard J. Schütz

    Curr. Prot. Pept. Sci., 12 (2011) 714-724.

    What can we learn from single molecule trajectories?

  12.  

  13. Verena Ruprecht, Julian Weghuber, Stefan Wieser, Gerhard J. Schütz

    in Advances in Planar Lipid Bilayers and Liposomes, edited by A. Iglic, Academic Press, 12 (2010) 21-40.

    Measuring Colocalization by Dual Color Single Molecule Imaging: Thresholds, Error Rates, and Sensitivity

  14.  

  15. J.Weghuber, M.Brameshuber, S.Sunzenauer, M.Lehner, C.Paar, T.Haselgrübler, M.Schwarzenbacher, M.Kaltenbrunner,
    C.Hesch, W.Paster, B.Heise, A.Sonnleitner, H.Stockinger & G.J.Schütz

    Methods Enzymol. 472 (2010) 133-151.

    Detection of protein-protein interactions in the live cell plasma membrane by quantifying prey redistribution upon bait micropatterning

  16.  

  17. Stefan Wieser & Gerhard J. Schütz

    Methods 46 (2008) 131-140.

    Tracking Single Molecules in the Live Cell Plasma Membrane – Do’s and Don’t’s

  18.  

  19. Mario Brameshuber, Gerhard J. Schütz

    Nat. Methods 5 (2008) 133-134.

    How the sum of its parts gets greater than the whole (News & Views)

  20.  

  21. Gerhard J. Schütz, Jan Hesse

    Laborwelt 8 (2007) 13-16.

    Hochempfindliche PCR-freie Genexpressionsanalye einzelner cDNAs

  22.  

  23. Jan Hesse, Gerhard J. Schütz

    J. Biotechnol 82 (2001) 25-35.

    Single Molecule Bioanalysis

  24.  

  25. A.Ebner, J.Madl, F.Kienberger, L.A.Chtcheglova, T.Puntheeranurak, R.Zhu, J.Tang, H.J.Gruber, G.J.Schütz, P.Hinterdorfer

    Current Nanoscience 3 (2007) 49-56.

    Single Molecule Force Microscopy on Cells and Biological Membranes

  26.  

  27. Jan Hesse, Max Sonnleitner, Gerhard J. Schütz

    Curr. Pharm. Biotechnol. 5 (2004) 309-319.

    Ultra-sensitive Fluorescence Reader for Bioanalysis

  28.  

  29. G.J.Schütz, P.Hinterdorfer

    Exp. Gerontol. 37 (2002) 1495-1511.

    Single Molecule Fluorescence and Force Microscopy

  30.  

  31. J.Hesse, C.Wechselberger, M.Sonnleitner, H.Schindler, G.J.Schütz

    J.Chromatography B, 782 (2002) 127-135

    Single Molecule Reader for Proteomics and Genomics

    This paper has been included in Proteomics Select - The Virtual Journal of Proteomics, 1/15 (2002).

  32.  

  33. P.Hinterdorfer, G.J.Schütz, F.Kienberger, H.Schindler

    J. Biotechnol 82 (2001) 25-35.

    Detection and characterization of single biomolecules at surfaces

  34.  

  35. G.J.Schütz, M.Axmann, and H.Schindler

    Single Mol. 2 (2001) 69-74.

    Imaging Single Molecules in Three Dimensions

  36.  

  37. G.J.Schütz, M.Sonnleitner, and H.Schindler

    J.Fluorescence 11 (2001) 177-185.

    Ultra-sensitive Microscopy of the Plasma Membrane of Living Cells

  38.  

  39. G.J.Schütz, M.Sonnleitner, P.Hinterdorfer, and H.Schindler

    Molec.Membr.Biol. 17 (2000) 17-29.

    Single Molecule Microscopy of Biomembranes (Review)

  40.  

     

Up

 

Book articles

     

     

  1. Johannes B. Huppa, Gerhard J. Schütz

    In: Ralph A Bradshaw and Philip D Stahl (Editors-in-Chief), Encyclopedia of Cell Biology, Vol 3, Waltham, MA: Academic Press, 2016, pp. 660-666.

    Single Molecule Methods to Measure Receptor–Ligand Interaction in Immunological Synapses

  2.  

  3. R. Zhu, M. Duman, J. Madl, G. J. Schütz, P. Hinterdorfer

    In: Cell Membrane Nanodomains editors: Alessandra Cambi and Diane S. Lidke. CRC Press 2014. 367-390

    Combined Topography, Recognition, and Fluorescence Measurements on Cells

  4.  

  5. M. Axmann, J. Madl, G. J. Schütz

    In: fluorescence microscopy – from principles to biological applications editor: Ulrich Kubitscheck. Wiley-Blackwell Weinheim Germany. 2013

    Single Molecule Microscopy in the Life Sciences

  6.  

  7. P. Lanzerstorfer , D. Borgmann, A. Steininger, S. Schaller, M. Brameshuber, S. Sunzenauer, G. J. Schütz, O. Höglinger, S. Winkler, J. Weghuber.

    In: Protein Purification and Analysis – Methods and Applications. iConcept press 2013

    Analysis of Protein-Protein Interactions in Live Cells - The Micro-Patterning Approach

  8.  

  9. M. Brameshuber and G. J. Schütz

    In: Springer Series on Fluorescence, Volume on far-field optical nanoscopy, volume editors P.Tinnefeld, C. Eggeling, S. W. Hell; in press

    In Vivo Tracking of Single Biomolecules: What Trajectories Tell Us About the Acting Forces

  10.  

  11. M. Brameshuber and G. J. Schütz

    In: Edward H. Egelman, editor: Comprehensive Biophysics 5, Membranes, Lukas Tamm. Oxford: Academic Press 2012. 337-365.

    Single Molecule Measurements in Membranes

  12.  

  13. Thomas Schmidt & Gerhard J. Schütz

    Handbook of Single Molecule Biophysics, Peter Hinterdorfer & Antoine van Oijen (eds.), Springer (2009)

    Single Molecule Analysis of Biomembranes

  14.  

  15. Jan Hesse, Thomas Haselgrübler, Christian Wechselberger, and Gerhard J. Schütz

    Single Molecule Biology, Alex Knight (ed.), Academic Press (2008)

    Single Molecule Microarray Analysis

  16.  

  17. Manuel Moertelmaier, Markus Axmann, Alois Sonnleitner, Werner Trabesinger, Hermann Gruber, Greg Harms, Andrew Woolley, Thomas Schmidt, Gerhard J. Schütz

    Recent Research Developments in Biophycis, 2 (2003) 95-119.

    Single Molecule Fluorescence Microscopy on Biomembranes

  18.  

  19. G.J.Schütz, H.Schindler

    Single Molecule Detection in Solution, Ch. Zander, J.Enderlein, R.A.Keller (eds.), Wiley-VCH 2002

    Single Dye Tracing for Ultrasensitive Microscopy on Living Cells

  20.  

  21. B.Pragl, H.J.Gruber, G.J.Schütz, M.Trieb, H.Prinz, H.-G.Knaus

    Recent Research Developments in Bioconjugate Chemistry, 1 (2002) 83-94.

    Fluorescently-labeled K+ channel toxins - tools to study K+ channels in native tissues.

  22.  

  23. C.K.Riener, G.Kada, C.Borken, F.Kienberger, P.Hinterdorfer, H.Schindler, G.J.Schütz, Th.Schmidt, C.D.Hahn, H.J.Gruber

    Recent Research Developments in Bioconjugate Chemistry, 1 (2002) 133-149.

    Bioconjugation for Biospecific Detection of Single Molecules in Atomic Force Microscopy (AFM) and in Single Dye Tracing.

Up